How Long Does Fioricet Stay In Your System?

What is Fioricet?

Fioricet is a combination medication for managing tension headaches and relaxing muscle contraction and migraine. It has three active ingredients, Butalbital, Acetaminophen, and caffeine which alleviate pain and it induces a calming effect on the mind and body.

It is indicated for the alleviation and management of tension headaches. And it relaxes muscle contraction in blood vessels to improve blood flow and mitigate pain. The onset action of the drug is 30 to 40 minutes, and the active duration is four to six hours. It is also used for managing migraine pain.

It belongs to the class of drugs called barbiturates, and it works by relaxing muscle contraction and causing sedation via enhancement of the inhibitory effects of GABA (a). Acetaminophen is an analgesic with antipyretic properties, and caffeine is thought to enhance the pain-relieving effects of acetaminophen. Butalbital has a half-life of about 35 hours, acetaminophen has a half-life of 12.5 hours to 3 hours, and caffeine has a half-life of about 2..5 to 4.5 hours.

It is a long-acting drug, and butalbital has the longest half-life. It takes eight to ten days to exit the system. In addition, it takes five to six half-lives to get rid of the system.

How long will the Fioricet pill show in a drug test?

If you take Fioricet regularly, the drug traces can be detected for much longer compared to those who take it on a PRN basis. Here, we have streamlined different drug tests that may detect through the different tests.

Urine: Several factors affect the detection window, but most urine tests will pick up butalbital three to seven days from the last dose.

Blood: As mentioned earlier, among all the active ingredients, butalbital has a very long life, and it can be detected in blood within eight days from the last use of the drug.

Saliva: Fioricet is detected in saliva for two to three days from the last dose of the drug 

Hair: All drugs have similar window detection, and fiorcet can be detected in hair for 90 days.

What are some factors that affect the Fiorcet detection window?

Several factors influence how long fiorcet stays in your system, including 

  • Strength and amount of use 
  • Frequency
  • Age 
  • Overall health

All these factors affect how long the drug will show up in different tests, and Butalbital is the longest-acting drug, and therefore the drug’s effect remains in the body for longer.

What are some side effects of Fioricet?

Commonly reported side effects to include:

  •  Dizziness
  •  Drowsiness
  •  Sedation 
  •  Vomiting
  •  shortness of breath
  •  Abdominal pain

Above mention side effects will wash off in a couple of days, and in case any side effects persist or worsen, inform your prescribing practitioner about it as he may adjust the dose.

Severe side effects of Fioricet are rare, and it is fairly tolerated here are severe side effects of Fioricet.

  • Allergic reaction 
  •  hives and blisters( swelling on lips, throat, and mouth)
  •  Headache 
  •  shaky feeling
  •  Seizures
  •  Mental confusion
  • Dry mouth
  • passing out 

 If you observe any symptoms, prompt medical intervention is required for early management.

How to take Fioricet?

Read the instruction on the package leaflet and follow the instruction on the packet: oral therapy, and you can take it with or without food as directed by your doctor.

Always take Fioricet four hours apart; if the pain symptoms do not subside, inform your doctor. Do not pop fiorcet on your own.

In case of a missed dose, take it as soon as possible, and the best bet is to take it as per your doctor’s instruction. If you are expecting a mother, you must inform your doctor.

If you are a lactating mother, it is best to avoid this medication as it may pass into breast milk and can cause sedation and drowsiness in a nursing baby.

Who should not take Fioricet?

Fioricet is FDA approved medication, and it is the first line of attack for managing tension-related headaches and migraine; however, it is not safe for everyone, and if you have any preexisting health condition, then you must inform your prescribing practitioner as he will adjust the dose if at all required. Do not take Fioricet if you have any of the below-mentioned conditions:

  • Allergic to the active ingredient of the fiorcet 
  • Enzyme disorder  
  • liver disease
  • Kidney disease
  • stomach problem 
  • Personal/family history of a drug and substance abuse
  • Stomach ulcer

Avoid Alcohol and marijuana as they can cause serious sedation and dizziness that can hurt the body. Preemptively share your medical history and the medication that you are taking – prescribed and street drugs.

Fioricet Detox

The factors that impact Fioricet withdrawal can also hurt detox. Detox is a process that is often tedious, and skipping any step would defeat the purpose of detox. The severity of withdrawal symptoms depends on the use of the drug, and the severity of symptoms depends on

The length of time it takes to get rid of is different for everyone, and it can take up to a week to get all the Fioricet out of the body. It is habit forming drug, and you can become addicted to it; therefore, it is important to take it for short periods and not take it for an extended time that can cause addiction. If you need detox, it is necessary to get it done through a certified detox treatment center for proper and holistic recovery. Always take it as per your doctor’s instruction to reduce the drug’s adverse and ill impact.


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